VHC - Virus Hépatologie Cancer | HENRI MONDOR

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   Guiliana AMADDEO

  PhD, PHU, MD,

Therapeutic trials and cohorts


The Hepatology Department of Henri Mondor Hospital is a reference center for the care of patients with hepatocellular carcinoma (HCC).

The specialized RCP "primary liver tumor" evaluates more than 30 HCC cases per week.

The Hepatology Department works in collaboration with the Departments of Oncology, Hepatobiliary Surgery, Nuclear Medicine, and Medical Imaging for the multidisciplinary management of patients with HCC.

Our goal is to test new molecules and innovative therapeutic procedures in the field of liver tumors, for example radioembolization.

Indeed, since 2007, numerous national and international phase 2 and 3 therapeutic trials (academic or industrial promotion) have been conducted in our department.

The CLIPP label "lymphoid tumors and primary tumors of the liver", awarded in 2015, led to the opening of a unit dedicated to early testing in collaboration with oncologists in April 2016, thus expanding the activity to phase 1 trials. This platform, dedicated to early testing, facilitates the design and implementation of early phase mono-centric trials.

The establishment of a cohort of patients with HCC is being initiated. More than 250 patients with HCC are supported each year at Mondor.

There are currently three areas of research:

  • Phase I/II adjuvant and neo-adjuvant therapeutic trials for the management of advanced HCC with the use of immunotherapy.
  • Studies on the diagnosis and characterization of HCC: several studies are being planned in collaboration with the department of anatomopathology, medical imaging, and nuclear medicine to improve the diagnosis and characterization of HCC.
  • Establishment of the CHC cohort at Mondor to improve care and build a medical network.

Team Members

  • Christophe Hézode, PhD, MD, PU-PH
  • Murielle François, Nurse


  • Sabine Colnot, INSERM U1016, CNRS UMR8104 - Cochin Institute
  • Giovanni Raimondo, AOU Policlinico "G. Martino" - Messina - Italie
  • Teresa Pollicino, AOU Policlinico "G. Martino" - Messina - Italie