PhD, MCU-PH, MD,
Dr. Julien Calderaro is an Associate Professor University-Hospital Practitioner in the Department of Pathology of Henri Mondor Hospital. He is specialized in medical and tumoral liver pathology. His research interests include the study of early mechanisms of hepatic carcinogenesis, the relationship between hepatic tumor phenotype and its molecular alterations, and the involvement of the immune microenvironment in tumor progression.
Hepatic carcinogenesis is a sequential process, and the molecular alterations involved in tumor progression are complex and varied. This molecular heterogeneity is associated with considerable phenotypic heterogeneity, with multiple histological variants reported. One goal of Dr. Calderaro's work is to determine the relationship between the microscopic aspect of hepatocellular carcinoma and its various molecular alterations. In situ image analysis approaches are also being developed to identify the various immune components of the tumor microenvironment.
Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification
J Hepatol. 2017
PD-L1 Expression and CD8+ T-cell Infiltrate are Associated with Clinical Progression in Patients with Node-positive Prostate Cancer
Eur Urol Focus. 2017
Germline and somatic DICER1 mutations in familial and sporadic liver tumors
J Hepatol. 2017
BRAF V600E mutational status in bile duct adenomas and hamartomas
Telomerase reverse transcriptase promoter mutation is an early somatic genetic alteration in the transformation of premalignant nodules in hepatocellular carcinoma on cirrhosis
Molecular characterization of hepatocellular adenomas developed in patients with glycogen storage disease type I
J Hepatol. 2013