The NRC's "hepatitis delta" laboratory for viral hepatitis B, C, and delta is located in the Virology Unit of the Clinical Microbiology Laboratory of the Paris Seine-Saint-Denis University Hospitals - UFR SMBH, Université Paris Nord (Bobigny). It is directed by Dr. Emmanuel Gordien.
Medical personnel assigned to the associated laboratory HDV:
Technical staff assigned to the associated laboratory HDV:
The following techniques are available at the hepatitis delta NRC:
Exam request should be accompanied by an information sheet duly completed and sent to the following address:
CNR ASSOCIÉ HÉPATITE VIRALE DELTA
125 RUE DE STALINGRAD
The associated laboratory HDV accepts the following types of samples : decanted and frozen serum, decanted and frozen plasma. For all other types of samples, please contact the NRC (Tel: 33148955611 / Fax : 33148955911 / mail : firstname.lastname@example.org).
The group is interested in the diversity of circulating hepatitis delta viruses and the consequences of this diversity on viral infection and pathogenesis. The research topics developed are:
The research of the laboratory has led to a new Delta virus classification system. Four new HDV genotypes have been characterized in the laboratory, such that HDV can now be classified into eight distinct genetic groups (or clades, or genotypes) all descended from a common ancestor (Radjef N., et al., 2014 and Le Gal F et al., 2016). This work led to the filing of an international patent on behalf of the Assistance Publique-Hôpitaux de Paris, "HDV Nucleic Acid Molecules, Their Fragments and Applications" (PCT/FR02/03239), in September 2001. The NRC has now characterized more than 2,500 HDV sequences.
In 2005, the laboratory developed the first consensus method for quantifying RNA viral load by real-time RT-PCR. This "in-house" technique was the subject of a patent application ("Quantification of VHD viral load by real-time PCR" - PCT/FR02/03239) in September 2005.