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Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.

Abdelhakim AHMED-BELKACEM, L Colliandre, Nazim AHNOU, Quentin NEVERS, M Gelin, Y Bessin, Rozenn BRILLET, O Cala, D Douguet, W Bourguet, I Krimm, Jean-Michel PAWLOTSKY, JF Guichou,

Nat Commun. 22/09/2016;7 : 12777 10.1038/ncomms12777.

Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.

L Colliandre, Nazim AHNOU, Quentin NEVERS, M Gelin, Y Bessin, Rozenn BRILLET, O Cala, D Douguet, W Bourguet, I Krimm, Jean-Michel PAWLOTSKY, JF Guichou, Abdelhakim AHMED-BELKACEM,

Nat Commun. 22/09/2016;7 : 12777 10.1038/ncomms12777.

New pseudodimeric aurones as palm pocket inhibitors of Hepatitis C virus RNA-dependent RNA polymerase.

A Meguellati, Abdelhakim AHMED-BELKACEM, A Nurisso, W Yi, Rozenn BRILLET, N Berqouch, L Chavoutier, A Fortune, Jean-Michel PAWLOTSKY, A Boumendjel, M Peuchmaur,

Eur J Med Chem. 10/06/2016;115 : 217-229 10.1016/j.ejmech.2016.03.005. 10/03/2016

B-ring modified aurones as promising allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase.

A Meguellati, Abdelhakim AHMED-BELKACEM, W Yi, R Haudecoeur, M Crouillere, Rozenn BRILLET, Jean-Michel PAWLOTSKY, A Boumendjel, M Peuchmaur,

Eur J Med Chem. 10/06/2014;80 : 579-592 10.1016/j.ejmech.2014.04.005 04/04/2014

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